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Article

Weak mutators can drive the evolution of fluoroquinolone resistance in Escherichia coli.

Antimicrobial agents and chemotherapy - 1 Oct 2006

Orlén Hanna, Hughes Diarmaid

Abstract excerpt

Weak mutators are common among clinical isolates of Escherichia coli. We show that the relative mutation rate and the "evolvability of fluoroquinolone resistance" are related by a power law slope of 1.2 over 3 orders of magnitude. Thus, even weak mutators can drive the evolution of fluoroquinolone resistance under selection pressure.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17005830
DOI: 10.1128/AAC.00783-06
PMCID: PMC1610101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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