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Article

Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women.

Journal of molecular medicine (Berlin, Germany) - 1 Dec 2006

Humphries Steve E, Gable David, Cooper Jackie A, Ireland Helen, Stephens Jeffrey W, Hurel Steven J, Li Ka Wah, Palmen Jutta, Miller Michelle A, Cappuccio Francesco P, Elkeles Robert, Godsland Ian, Miller George J, Talmud Philippa J

Abstract excerpt

Common variants of TCF7L2, encoding a beta-cell-expressed transcription factor, are strongly associated with increased risk of type 2 diabetes (T2D). We examined this association using both prospective and case-control designs. A total of 2,676 healthy European white middle-aged men from the prospective NPHSII (158 developed T2D over 15 years surveillance) were genotyped for two intronic SNPs [rs 7903146...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17665514
DOI: 10.1007/s00109-006-0108-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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