Article
Pro- and antiatherogenic effects of a dominant-negative P465L mutation of peroxisome proliferator-activated receptor-γ in apolipoprotein E-Null mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2012
Pendse Avani A, Johnson Lance A, Kim Hyung-Suk, McNair Marcus, Nipp C Taylor, Wilhelm Carolyn, Maeda Nobuyo
Abstract excerpt
OBJECTIVE: The dominant-negative mutation, P467L, in peroxisome proliferator-activated receptor-γ (PPARγ) affects adipose tissue distribution, insulin sensitivity, and blood pressure in heterozygous humans. We hypothesized that the equivalent mutation, PPARγ-P465L, in mice will worsen atherosclerosis. METHODS AND RESULTS: Apolipoprotein E-null mice with and without PPARγ-P465L mutation were bred in 129S6 inbred...
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