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Article

Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma.

The Journal of clinical investigation - 1 Jul 2004

Tsai Yau-Sheng, Kim Hyo-Jeong, Takahashi Nobuyuki, Kim Hyung-Suk, Hagaman John R, Kim Jason K, Maeda Nobuyo

Abstract excerpt

Peroxisome proliferator-activated receptor gamma (PPARgamma), the molecular target of a class of insulin sensitizers, regulates adipocyte differentiation and lipid metabolism. A dominant negative P467L mutation in the ligand-binding domain of PPARgamma in humans is associated with severe insulin...

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Identifiers

PMID: 15254591
DOI: 10.1172/JCI20964
PMCID: PMC449746

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15254591-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma.PMID 15254591Read ↗

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