Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma.

Abstract excerpt

Peroxisome proliferator-activated receptor gamma (PPARgamma), the molecular target of a class of insulin sensitizers, regulates adipocyte differentiation and lipid metabolism. A dominant negative P467L mutation in the ligand-binding domain of PPARgamma in humans is associated with severe insulin resistance and hypertension. Homozygous mice with the equivalent P465L mutation die in utero. Heterozygous mice grow...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adipose Tissue
• Share to Blood Glucose