Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Translesion synthesis past tamoxifen-derived DNA adducts by human DNA polymerases eta and kappa.

Biochemistry - 3 Oct 2006

Yasui Manabu, Suzuki Naomi, Laxmi Y R Santosh, Shibutani Shinya

Abstract excerpt

The long-term treatment of tamoxifen (TAM), widely used for adjuvant chemotherapy and chemoprevention for breast cancer, increases a risk of developing endometrial cancer. A high frequency of K-ras mutations has been observed in the endometrium of women treated with TAM. Human DNA polymerase (pol) eta and pol kappa are highly expressed in the reproductive organs and are associated with translesion synthesis past...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemotherapy, Adjuvant
Share to Deoxyribonucleotides
Share to DNA Adducts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endometrial Neoplasms

Share to Endometrium

Share to Oncogene Protein p21(ras)

Share to Stereoisomerism

Share to Tamoxifen

Source

Open in PubMed Open full text

Identifiers

PMID: 17002316
DOI: 10.1021/bi0608461
PMCID: PMC2593916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Translesion synthesis past tamoxifen-derived DNA adducts by human DNA polymerases eta and kappa.PMID 17002316Read ↗

Translesion synthesis past estrogen-derived DNA adducts by human DNA polymerases eta and kappa.Semantic proximity Read ↗

Miscoding properties of 6alpha- and 6beta-diastereoisomers of the N(2)-(estradiol-6-yl)-2'-deoxyguanosine DNA adduct by Y-family human DNA polymerases.Semantic proximity Read ↗

Miscoding properties of 2'-deoxyinosine, a nitric oxide-derived DNA Adduct, during translesion synthesis catalyzed by human DNA polymerases.Semantic proximity Read ↗

Translesional synthesis on a DNA template containing N2-methyl-2'-deoxyguanosine catalyzed by the Klenow fragment of Escherichia coli DNA polymerase I.Semantic proximity Read ↗

Bypass of Mutagenic O(6)-Carboxymethylguanine DNA Adducts by Human Y- and B-Family Polymerases.Semantic proximity Read ↗

Enzymatic bypass of an N6-deoxyadenosine DNA-ethylene dibromide-peptide cross-link by translesion DNA polymerases.Semantic proximity Read ↗

Error-prone translesion synthesis by human DNA polymerase eta on DNA-containing deoxyadenosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.Semantic proximity Read ↗

Miscoding by the exocyclic and related DNA adducts 3,N4-etheno-2'-deoxycytidine, 3,N4-ethano-2'-deoxycytidine, and 3-(2-hydroxyethyl)-2'-deoxyuridine.Semantic proximity Read ↗

In vitro miscoding of alkylthymines with DNA and RNA polymerases.Semantic proximity Read ↗

Mutagenic specificity of model estrogen-DNA adducts in mammalian cells.Semantic proximity Read ↗

In vitro mispairing specificity of O2-ethylthymidine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.