Article
Mutagenic specificity of model estrogen-DNA adducts in mammalian cells.
Biochemistry - 16 Jun 1998
Terashima I, Suzuki N, Itoh S, Yoshizawa I, Shibutani S
Abstract excerpt
Site-specifically modified oligodeoxynucleotides were used to explore the mutagenic properties of the model estrogen-DNA adducts N2-[3-methoxyestra-1,3,5(10)-trien-6(alpha, beta)-yl]-2'-deoxyguanosine (dG-N2-3MeE) and N6-[3-methoxyestra-1,3, 5(10)-trien-6(alpha,beta)-yl]-2'-deoxyadenosine (dA-N6-3MeE) in simian kidney (COS-7) cells. Oligodeoxynucleotides (5'TCCTCCTCXCCTCTC; X = dG, dA, dG-N2-3MeE, or dA-N6-3MeE)...
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