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Article

Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade

25 Sept 2006

Abstract excerpt

The programmed death (PD)-1-PD-1 ligand (PD-L) pathway, which is part of the B7-CD28 family, consists of the PD-1 receptor and its two ligands PD-L1 and PD-L2. Engagement of PD-1 by its ligands inhibits immune responses, and recent work has shown that PD-1 is highly expressed on exhausted T cells during chronic lymphocytic choriomeningitis virus (LCMV) infection in mice. Blockade of this pathway reinvigorates the...

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PMID: 17000870
DOI: 10.1084/jem.20061800

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