Article
Genetic susceptibility to environmental carcinogenesis in Slovenian melanoma patients.
Acta dermatovenerologica Alpina, Pannonica, et Adriatica - 1 Jun 2006
Dolzan V, Rudolf Z, Breskvar K
Abstract excerpt
The skin acts as the first defence barrier against external environmental pollutants, including chemicals and UV radiation. Cytochrome P450 CYP1A1 and glutathione S-transferases (GSTs) found in melanocytes and skin basal layers were shown to participate both in the metabolism of xenobiotics and in detoxification of reactive oxygen species (ROS). In our study we analysed the distribution of single and combined...
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