Article
Protective effect of copy number polymorphism of glutathione S-transferase T1 gene on melanoma risk in presence of CDKN2A mutations, MC1R variants and host-related phenotypes.
Familial cancer - 1 Jan 2009
Chaudru Valérie, Lo M T, Lesueur F, Marian C, Mohamdi H, Laud K, Barrois M, Chompret A, Avril M F, Demenais F, Bressac-de Paillerets B
Abstract excerpt
The effect of CDKN2A, the major high-risk melanoma susceptibility gene, has been shown to be modified by host-related phenotypes and variants of MC1R gene. The glutathione S-transferase (GSTs) genes, implicated in detoxification of metabolites after UV exposure, are candidates for modulating CDKN2A penetrance. Few case-control studies have investigated the effect of GSTs on melanoma risk, and have led to...
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