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Article

Folding of Fibroblast Growth Factor 1 Is Critical for Its Nonclassical Release.

Biochemistry - 23 Feb 2016

Prudovsky Igor, Kacer Doreen, Davis Julie, Shah Varun, Jayanthi Srinivas, Huber Isabelle, Dakshinamurthy Rajalingam, Ganter Owen, Soldi Raffaella, Neivandt David, Guvench Olgun, Suresh Kumar Thallapuranam Krishnaswamy

Abstract excerpt

Fibroblast growth factor 1 (FGF1), a ubiquitously expressed pro-angiogenic protein that is involved in tissue repair, carcinogenesis, and maintenance of vasculature stability, is released from the cells via a stress-dependent nonclassical secretory pathway. FGF1 secretion is a result of transmembrane translocation of this protein. It correlates with the ability of FGF1 to permeabilize membranes composed of acidic...

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Identifiers

PMID: 26836284
DOI: 10.1021/acs.biochem.5b01341
PMCID: PMC5534326

Genes

FGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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