Translokin is an intracellular mediator of FGF-2 trafficking.

doi:10.1038/ncb979

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Article

Translokin is an intracellular mediator of FGF-2 trafficking.

Nature cell biology - 1 May 2003

Bossard Carine, Laurell Henrik, Van den Berghe Loïc, Meunier Sylvain, Zanibellato Catherine, Prats Hervé

Abstract excerpt

Basic fibroblast growth factor (bFGF or FGF-2) exerts its pleiotropic activities both as an exogenous and an intracellular factor. FGF-1 and FGF-2 are prototypes for this dual signalling, but the mechanisms of their intracellular actions remain unknown. Here we show that Translokin, a cytoplasmic protein of relative molecular mass 55,000 (M(r) 55K), interacts specifically with the 18K form of FGF-2. Translokin is...

Topics

3T3 Cells
Active Transport, Cell Nucleus
Amino Acid Sequence
Animals
Base Sequence
COS Cells
Carrier Proteins
Cell Cycle Proteins
Cell Nucleus
Cytoplasm
Eukaryotic Cells
Fibroblast Growth Factor 1
Fibroblast Growth Factor 2
Fluorescent Antibody Technique

Source

Open in PubMed

Identifiers

PMID: 12717444
DOI: 10.1038/ncb979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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