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Article

A Binding Site for Steroidogenic Factor-1 is Part of a Complex Enhancer that Mediates Expression of the Murine Gonadotropin-Releasing Hormone Receptor Gene1

1 Jan 1997

Abstract excerpt

Expression of the GnRH receptor (GnRH-R) gene in the anterior pituitary gland, as with the genes encoding the gonadotropin subunits, is restricted to gonadotrophs. Thus, it is conceivable that a common mechanism is involved in activating cell-specific expression of these genes. In fact, expression of the alpha- and LHbeta-subunit genes appears to require binding of the nuclear orphan receptor, steroidogenic...

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Identifiers

PMID: 9002645
DOI: 10.1095/biolreprod56.1.160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A Binding Site for Steroidogenic Factor-1 is Part of a Complex Enhancer that Mediates Expression of the Murine Gonadotropin-Releasing Hormone Receptor Gene1PMID 9002645Read ↗

Stimulation of luteinizing hormone beta gene promoter activity by the orphan nuclear receptor, steroidogenic factor-1.Semantic proximity Read ↗

Steroidogenic Factor-1 Interacts with a Gonadotrope-Specific Element within the First Exon of the Human Gonadotropin-Releasing Hormone Receptor Gene to Mediate Gonadotrope-Specific Expression*Semantic proximity Read ↗

A microdeletion in the ligand binding domain of human steroidogenic factor 1 causes XY sex reversal without adrenal insufficiency.Semantic proximity Read ↗

Sp1, steroidogenic factor 1 (SF-1), and early growth response protein 1 (egr-1) binding sites form a tripartite gonadotropin-releasing hormone response element in the rat luteinizing hormone-beta gene promoter: an integral role for SF-1.Semantic proximity Read ↗

Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues.Semantic proximity Read ↗

Regulation of the Orphan Nuclear Receptor Steroidogenic Factor 1 by Sox ProteinsSemantic proximity Read ↗

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Characterization of the promoter of SF-1, an orphan nuclear receptor required for adrenal and gonadal development.Semantic proximity Read ↗

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Expression of steroidogenic factor 1 in the testis requires an E box and CCAAT box in its promoter proximal region.Semantic proximity Read ↗

Oct-1 and nuclear factor Y bind to the SURG-1 element to direct basal and gonadotropin-releasing hormone (GnRH)-stimulated mouse GnRH receptor gene transcription.Semantic proximity Read ↗

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