Article
Individuals who are homozygous for the 2282del4 and R501X filaggrin null mutations do not always develop dermatitis and complete long-term remission is possible.
Journal of the European Academy of Dermatology and Venereology : JEADV - 1 Mar 2012
Thyssen J P, Carlsen B C, Bisgaard H, Giwercman C, Johansen J D, Linneberg A, Meldgaard M, Szecsi P B, Stender S, Menné T
Abstract excerpt
BACKGROUND: About 8-10% of the general population in Europe carry a null mutation in the filaggrin gene which is associated with early onset of atopic dermatitis as well as persistence into adulthood. No studies have investigated whether individuals with the homozygous filaggrin null genotype always develop dermatitis. OBJECTIVES: The aim of this study was to describe the natural history of individuals with no...
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