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Inspecting the Ribozyme Region of Hepatitis Delta Virus Genotype 1: Conservation and Variability.

Viruses - 22 Jan 2022

Pacin-Ruiz Beatriz, Cortese María Francesca, Tabernero David, Sopena Sara, Gregori Josep, García-García Selene, Casillas Rosario, Najarro Adrián, Aldama Unai, Palom Adriana, Rando-Segura Ariadna, Galán Anna, Vila Marta, Riveiro-Barciela Mar, Quer Josep, González-Aseguinolaza Gloria, Buti María, Rodríguez-Frías Francisco

Abstract excerpt

The hepatitis delta virus (HDV) genome has an autocatalytic region called the ribozyme, which is essential for viral replication. The aim of this study was to use next-generation sequencing (NGS) to analyze the ribozyme quasispecies (QS) in order to study its evolution and identify highly conserved regions potentially suitable for a gene-silencing strategy. HDV RNA was extracted from 2 longitudinal samples of...

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Source

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Identifiers

PMID: 35215809
DOI: 10.3390/v14020215
PMCID: PMC8877431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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