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Article

RNA binding candidates for human ADAR3 from substrates of a gain of function mutant expressed in neuronal cells

18 Sept 2019

Abstract excerpt

Human ADAR3 is a catalytically inactive member of the Adenosine Deaminase Acting on RNA (ADAR) protein family, whose active members catalyze A-to-I RNA editing in metazoans. Until now, the reasons for the catalytic incapability of ADAR3 has not been defined and its biological function rarely explored. Yet, its exclusive expression in the brain and involvement in learning and memory suggest a central role in the...

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PMID: 31552420
DOI: 10.1093/nar/gkz815

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