Article
Drosophila BAP60 is an essential component of the Brahma complex, required for gene activation and repression.
Journal of molecular biology - 16 Sept 2005
Möller André, Avila Frank W, Erickson James W, Jäckle Herbert
Abstract excerpt
The SWI/SNF-like chromatin remodeling complex of Drosophila, the Brahma complex, contains four subunits (Brahma, BAP155/Moira, SNR1 and BAP60) conserved from yeast to humans. A reconstituted human complex lacking the BAP60 homolog shows full remodeling activity, suggesting that BAP60 is not essential for the core function. We generated Drosophila mutants and found that BAP60 carries a vital function and...
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