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Article

Granule neurons in cerebellum express distinct splice variants of the inositol trisphosphate receptor that are modulated by calcium.

American journal of physiology. Cell physiology - 1 Oct 2004

Choi Joseph Y, Beaman-Hall Carol M, Vallano Mary L

Abstract excerpt

Primary cultures of granule cells (GC) from rat cerebellar cortex were used to determine whether bioelectric activity, via a Ca(2+)/calmodulin-dependent kinase (CaMK) signaling cascade, modulates expression and exon selection in the inositol trisphosphate receptor type 1 (IP(3)R1). IP(3)R1 contains or lacks three exons (S1, S2, and S3) that are regulated in a regionally and temporally specific manner. The...

Topics

Animals
Animals, Newborn
Blotting, Western
Calcium
Calcium Channels
Calcium Signaling
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Cells, Cultured
Cerebellum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Enzyme Activation

Enzyme Inhibitors

Fluorescent Antibody Technique

Inositol 1,4,5-Trisphosphate Receptors

N-Methylaspartate

Neurons

Phenotype

Potassium Chloride

Source

Identifiers

PMID: 15189817
DOI: 10.1152/ajpcell.00571.2003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15189817-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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