Article
Regulation of wingless signaling by the CKI family in Drosophila limb development.
Developmental biology - 1 Nov 2006
Zhang Lei, Jia Jianhang, Wang Bing, Amanai Kazuhito, Wharton Keith A, Jiang Jin
Abstract excerpt
The Wingless (Wg)/Wnt signaling pathway regulates a myriad of developmental processes and its malfunction leads to human disorders including cancer. Recent studies suggest that casein kinase I (CKI) family members play pivotal roles in the Wg/Wnt pathway. However, genetic evidence for the involvement of CKI family members in physiological Wg/Wnt signaling events is lacking. In addition, there are conflicting...
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