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Article

NAD(P)H oxidase activity of Nox4 in chondrocytes is both inducible and involved in collagenase expression.

Antioxidants & redox signaling - 1 Jan 2000

Grange Laurent, Nguyen Minh Vu Chuong, Lardy Bernard, Derouazi Madiha, Campion Yannick, Trocme Candice, Paclet Marie-Helene, Gaudin Philippe, Morel Francoise

Abstract excerpt

Reactive oxygen species (ROS) are regulators of redox-sensitive cell signaling pathways. In osteoarthritis, human interleukin-1beta is implicated in cartilage destruction through an ROS-dependent matrix metalloproteinase production. To determine the molecular source of ROS production in the human IL-1beta (hIL-1beta)-sensitive chondrocyte immortalized cell line C-20/A4, transfected cells were constructed that...

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Identifiers

PMID: 16987005
DOI: 10.1089/ars.2006.8.1485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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