Article

MicroRNA-182-5p protects human lens epithelial cells against oxidative stress-induced apoptosis by inhibiting NOX4 and p38 MAPK signalling

2020-06-01

Abstract excerpt

<h4>Background: </h4> MicroRNAs (miRNAs) are abnormally expressed in various ocular diseases, including age-related cataract. However, the role of miR-182-5p in the progression of age-related cataract remains unclear. <h4>Methods: </h4>: The expression of miR-182-5p in HLE-B3 cells was detected by qRT-PCR. HLE-B3 cells were transfected with miR-182-5p mimics. CCK-8, EdU, flow cytometry, 2',7'-dichlorodihydrofluore...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f72ff8f1-66b0-5874-aa5f-46915b22e2ce
DOI: 10.21203/rs.3.rs-16028/v3

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MicroRNA-182-5p protects human lens epithelial cells against oxidative stress-induced apoptosis by inhibiting NOX4 and p38 MAPK signallingDOI 10.21203/rs.3.rs-16028/v3Read

Decorin inhibits glucose-induced lens epithelial cell apoptosis via suppressing p22 <sup>phox</sup> -p38 MAPK signaling pathwaySemantic proximity Read

Slit2 Promotes H 2 O 2 -Induced Lens Epithelial Cells Oxidative Damage and Age-Related CataractSemantic proximity Read

Changes in SIRT1 Expression and Its Downstream Pathways in Age-Related Cataract in HumansSemantic proximity Read

Identification of H2O2 induced oxidative stress associated microRNAs in HLE-B3 cells and their clinical relevance to the progression of age-related nuclear cataractSemantic proximity Read

MicroRNA-204-5p attenuates oxidative stress, apoptosis and inflammation by targeting TXNIP in diabetic cataractSemantic proximity Read

High-expression of ROCK1 modulates the apoptosis of lens epithelial cells in age-related cataracts by targeting p53 geneSemantic proximity Read

Identification of genes asscoiated with pyroptosis in Age-related cataract of using bioinformatics analysesSemantic proximity Read

Identification of tRNA-derived small RNAs expression profiles and their potential functions in age-related cataractSemantic proximity Read

MicroRNA-34a promoting apoptosis of human lens epithelial cells through down-regulation of B-cell lymphoma-2 and silent information regulatorSemantic proximity Read

Cytoprotective effects of hypoxia against oxidative stress in human lens epithelial cells by up-regulating Nrf2 expressionSemantic proximity Read

Downregulated miR-181a alleviates H2O2-induced oxidative stress and cellular senescence by targeting PDIA6 in human foreskin fibroblastsSemantic proximity Read

Nanoeugenol Prevents Apoptotic Damage in Selenite-induced Cataracts in Cultured Lenses From Wistar Rats and in Human Lenticular Epithelial Cell Lines: Molecular ValidationSemantic proximity Read