Article
Impaired generation of reactive oxygen species in leprechaunism through downregulation of Nox4.
Diabetes - 1 Nov 2005
Park Hye Sun, Jin Dong Kyu, Shin Sang Min, Jang Mi Kyung, Longo Nicholas, Park Ji Won, Bae Duk Soo, Bae Yun Soo
Abstract excerpt
Leprechaunism features a clinical constellation characterized by extreme insulin resistance, growth retardation, and several distinct developmental abnormalities. One puzzling observation about leprechaunism is that mutations in the insulin receptor gene frequently associated with this syndrome cannot account for the aberrant responses of cultured cells to other growth factors. Here we report that the generation...
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