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Article

Mutational analysis of the consensus sequence of a replication origin from yeast chromosome III.

Molecular and cellular biology - 1 Aug 1990

Van Houten J V, Newlon C S

Abstract excerpt

Yeast autonomously replicating sequence (ARS) elements contain an 11-base-pair core consensus sequence (5'-[A/T]TTTAT[A/G]TTT[A/T]-3') that is required for function. The contribution of each position within this sequence to ARS activity was tested by creating all possible single-base mutations within the core consensus sequence of ARS307 (formerly called the C2G1 ARS) and testing their effects on high-frequency...

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Identifiers

PMID: 2196439
DOI: 10.1128/mcb.10.8.3917-3925.1990
PMCID: PMC360902

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