A yeast chromosomal origin of DNA replication defined by multiple functional elements.

doi:10.1126/science.1536007

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Article

A yeast chromosomal origin of DNA replication defined by multiple functional elements.

Science (New York, N.Y.) - 14 Feb 1992

Marahrens Y, Stillman B

Abstract excerpt

Although it has been demonstrated that discrete origins of DNA replication exist in eukaryotic cellular chromosomes, the detailed organization of a eukaryotic cellular origin remains to be determined. Linker substitution mutations were constructed across the entire Saccharomyces cerevisiae chromosomal origin, ARS1. Functional studies of these mutants revealed one essential element (A), which includes a match to...

Topics

Amino Acid Sequence
Base Sequence
Chromosome Mapping
Chromosomes, Fungal
DNA Replication
DNA, Fungal
DNA-Binding Proteins
Fungal Proteins
Gene Expression Regulation, Fungal
Genetic Linkage
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Plasmids

Replicon

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Trans-Activators

Transcription Factors

Source

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Identifiers

PMID: 1536007
DOI: 10.1126/science.1536007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1536007-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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