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Article

A yeast chromosomal origin of DNA replication defined by multiple functional elements.

Science (New York, N.Y.) - 14 Feb 1992

Marahrens Y, Stillman B

Abstract excerpt

Although it has been demonstrated that discrete origins of DNA replication exist in eukaryotic cellular chromosomes, the detailed organization of a eukaryotic cellular origin remains to be determined. Linker substitution mutations were constructed across the entire Saccharomyces cerevisiae chromosomal origin, ARS1. Functional studies of these mutants revealed one essential element (A), which includes a match to...

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PMID: 1536007
DOI: 10.1126/science.1536007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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