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Article

Role of toll-like receptor signalling in Abeta uptake and clearance.

Brain : a journal of neurology - 1 Nov 2006

Tahara Kazuki, Kim Hong-Duck, Jin Jing-Ji, Maxwell J Adam, Li Ling, Fukuchi Ken-ichiro

Abstract excerpt

Deposits of amyloid beta-protein (Abeta) in neuritic plaques and cerebral vessels are a pathological hallmark of Alzheimer's disease. Fibrillar Abeta deposits are closely associated with inflammatory responses such as activated microglia in brain with this disease. Increasing lines of evidence support the hypothesis that activated microglia, innate immune cells in the CNS, play a pivotal role in the progression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16984903
DOI: 10.1093/brain/awl249
PMCID: PMC2445613

Genes

TLR4
TLR9
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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