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Article

TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease.

Journal of neuroinflammation - 9 Aug 2011

Song Min, Jin Jingji, Lim Jeong-Eun, Kou Jinghong, Pattanayak Abhinandan, Rehman Jamaal A, Kim Hong-Duck, Tahara Kazuki, Lalonde Robert, Fukuchi Ken-ichiro

Abstract excerpt

BACKGROUND: Amyloid plaques, a pathological hallmark of Alzheimer's disease (AD), are accompanied by activated microglia. The role of activated microglia in the pathogenesis of AD remains controversial: either clearing Aβ deposits by phagocytosis or releasing proinflammatory cytokines and cytotoxic substances. Microglia can be activated via toll-like receptors (TLRs), a class of pattern-recognition receptors in...

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Source

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Identifiers

PMID: 21827663
DOI: 10.1186/1742-2094-8-92
PMCID: PMC3169468

Genes

TLR4
CCL3
CCL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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