Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deletion of CD14 Attenuates Alzheimer's Disease Pathology by Influencing the Brain's Inflammatory Milieu

17 Nov 2010

Abstract excerpt

Alzheimer's disease (AD) is characterized by the deposition of β-amyloid (Aβ)-containing plaques within the brain that is accompanied by a robust microglial-mediated inflammatory response. This inflammatory response is reliant upon engagement of innate immune signaling pathways involving the toll-like receptors (TLRs). Studies assessing the roles of TLRs in AD pathogenesis have yielded conflicting results. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Immune Response and Inflammation
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21084593
DOI: 10.1523/jneurosci.2637-10.2010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of CD14 Attenuates Alzheimer's Disease Pathology by Influencing the Brain's Inflammatory MilieuPMID 21084593Read ↗

TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease.Semantic proximity Read ↗

Loss of interleukin receptor-associated kinase 4 signaling suppresses amyloid pathology and alters microglial phenotype in a mouse model of Alzheimer's disease.Semantic proximity Read ↗

TLR4 Gene Expression and Pro-Inflammatory Cytokines in Alzheimer’s Disease and in Response to Hippocampal Deafferentation in RodentsSemantic proximity Read ↗

Toll-like receptors in Alzheimer's disease.Semantic proximity Read ↗

Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology.Semantic proximity Read ↗

Microglial toll-like receptors and Alzheimer’s diseaseSemantic proximity Read ↗

Role of toll-like receptor signalling in Abeta uptake and clearance.Semantic proximity Read ↗

Identification and modification of amyloid-independent phenotypes of APOE4 mice.Semantic proximity Read ↗

The human-specific<i>CASP4</i>gene product contributes to Alzheimer-related synaptic and behavioural deficitsSemantic proximity Read ↗

Reprint of: Microglial toll-like receptors and Alzheimer’s diseaseSemantic proximity Read ↗

Microglial C5aR (CD88) expression correlates with amyloid-beta deposition in murine models of Alzheimer's disease.Semantic proximity Read ↗

Association between the polymorphisms of TLR4 and CD14 genes and Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.