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Article

The E3 ubiquitin ligase CHIP mediates ubiquitination and proteasomal degradation of PRMT5.

Biochimica et biophysica acta - 1 Feb 2016

Zhang Huan-Tian, Zeng Ling-Fei, He Qing-Yu, Tao W Andy, Zha Zhen-Gang, Hu Chang-Deng

Abstract excerpt

Protein arginine methyltransferase 5 (PRMT5) is an important member of the protein arginine methyltransferase family that regulates many cellular processes through epigenetic control of target gene expression. Because of its overexpression in a number of human cancers and its essential role in cell proliferation, transformation, and cell cycle progression, PRMT5 has been recently proposed to function as an...

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Identifiers

PMID: 26658161
DOI: 10.1016/j.bbamcr.2015.12.001
PMCID: PMC5397900

Genes

PRMT5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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