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Quantitative SUMO proteomics identifies PIAS1 substrates involved in cell migration and motility

11 Feb 2020

Abstract excerpt

The protein inhibitor of activated STAT1 (PIAS1) is an E3 SUMO ligase that plays important roles in various cellular pathways. Increasing evidence shows that PIAS1 is overexpressed in various human malignancies, including prostate and lung cancers. Here we used quantitative SUMO proteomics to identify potential substrates of PIAS1 in a system-wide manner. We identified 983 SUMO sites on 544 proteins, of which 62...

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PMID: 32047143
DOI: 10.1038/s41467-020-14581-w

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