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Article

Symmetric signaling by an asymmetric 1 erythropoietin: 2 erythropoietin receptor complex.

Molecular cell - 30 Jan 2009

Zhang Yingxin L, Radhakrishnan Mala L, Lu Xiaohui, Gross Alec W, Tidor Bruce, Lodish Harvey F

Abstract excerpt

Via sites 1 and 2, erythropoietin binds asymmetrically to two identical receptor monomers, although it is unclear how asymmetry affects receptor activation and signaling. Here we report the design and validation of two mutant erythropoietin receptors that probe the role of individual members of the receptor dimer by selectively binding either site 1 or site 2 on erythropoietin. Ba/F3 cells expressing either...

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Identifiers

PMID: 19187767
DOI: 10.1016/j.molcel.2008.11.026
PMCID: PMC2706114

Genes

JAK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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