Article
Dominant action of mutated erythropoietin receptors on differentiation in vitro and erythroleukemia development in vivo.
Oncogene - 17 Feb 2000
Cull V, Tilbrook P A, Adenan A S, Chappell D, Ingley E, Sarna M K, Palmer T N, Watowich S S, Klinken S P
Abstract excerpt
J2E cells produce rapid, fatal erythroleukemias in vivo but still respond to erythropoietin (epo) in vitro by differentiating, proliferating and remaining viable in the absence of serum. Mutant epo receptors were introduced into these cells to determine whether they could influence the different biological responses to epo in vitro and the development of erythroleukemias. Three mutant receptors were used as...
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