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Article

Toll-like receptor 4 polymorphisms and idiopathic chromosomally normal miscarriage.

Human reproduction (Oxford, England) - 1 Feb 2007

Hirschfeld A F, Jiang R, Robinson W P, McFadden D E, Turvey S E

Abstract excerpt

BACKGROUND: Lipopolysaccharide (LPS or endotoxin) exposure resulting from microbial invasion of the endometrium disturbs the Th1/Th2 balance at the feto-maternal interface and has been linked to the risk of idiopathic miscarriage in a range of human and animal studies. Toll-like receptor 4 (TLR4) mediates LPS signalling, and the human TLR4 gene harbours two single-nucleotide polymorphisms (SNPs) known to reduce...

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Source

Identifiers

PMID: 16982657
DOI: 10.1093/humrep/del377

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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