Article
Fetal HLA-G alleles and their effect on miscarriage.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University - 1 Sept 2018
Koc Altug, Kirbiyik Ozgur, Kutbay Yasar B, Ozyilmaz Berk, Ozdemir Taha R, Kaya Ozge Ozer, Kubat Gozde, Koc Zeynep Peker
Abstract excerpt
BACKGROUND: Immunosuppression at the feto-maternal interface is crucial for a successful pregnancy outcome. Human leukocyte antigen-G (HLA-G) seems to be a major contributor to fetal tolerance. The HLA-G expression is seen in cytotrophoblasts and in maternal blood. Fetal HLA-G acts on decidual antigen-presenting cells (APCs), natural killers (NKs) and T cells. Recent findings revealed that defects in placentation...
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