Article
Maternal TLR4 and NOD2 gene variants, pro-inflammatory phenotype and susceptibility to early-onset preeclampsia and HELLP syndrome.
PloS one - 2 Apr 2008
van Rijn Bas B, Franx Arie, Steegers Eric A P, de Groot Christianne J M, Bertina Rogier M, Pasterkamp Gerard, Voorbij Hieronymus A M, Bruinse Hein W, Roest Mark
Abstract excerpt
BACKGROUND: Altered maternal inflammatory responses play a role in the development of preeclampsia and the hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome. We examined whether allelic variants of the innate immune receptors Toll-like receptor 4 (TLR4) and nucleotide-binding oligomerization domain 2 (NOD2), that impair the inflammatory response to endotoxin, are related to preeclampsia and...
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