Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alpha-synuclein facilitates the toxicity of oxidized catechol metabolites: implications for selective neurodegeneration in Parkinson's disease.

FEBS letters - 3 Apr 2006

Hasegawa Takafumi, Matsuzaki-Kobayashi Michiko, Takeda Atsushi, Sugeno Naoto, Kikuchi Akio, Furukawa Katsutoshi, Perry George, Smith Mark A, Itoyama Yasuto

Abstract excerpt

Free radicals, including dopamine (DA)-oxidized metabolites, have long been implicated in pathogenesis of Parkinson's disease (PD). However, the relationships between such oxidative stresses and alpha-synuclein (alpha-S), a major constituent of Lewy bodies, remain unknown. In this study, we established neuronal cells that constitutively express alpha-S and tetracycline-regulated tyrosinase. While tyrosinase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Catechols

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Comet Assay

Share to Intracellular Membranes

Share to Mitochondrial Membranes

Share to Monophenol Monooxygenase

Share to Multiprotein Complexes

Share to Nerve Degeneration

Source

Identifiers

PMID: 16567160
DOI: 10.1016/j.febslet.2006.03.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alpha-synuclein facilitates the toxicity of oxidized catechol metabolites: implications for selective neurodegeneration in Parkinson's disease.PMID 16567160Read ↗

Dopamine Cytotoxicity Involves Both Oxidative and Nonoxidative Pathways in SH-SY5Y Cells: Potential Role of Alpha-Synuclein Overexpression and Proteasomal Inhibition in the Etiopathogenesis of Parkinson's DiseaseSemantic proximity Read ↗

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity.Semantic proximity Read ↗

Parkinson's disease genetic mutations increase cell susceptibility to stress: mutant alpha-synuclein enhances H2O2- and Sin-1-induced cell death.Semantic proximity Read ↗

α-Synuclein overexpression increases dopamine toxicity in BE(2)-M17 cellsSemantic proximity Read ↗

[Cellular pathophysiology of Parkinson's disease].Semantic proximity Read ↗

[Free radicals and ailing proteins--the culprits behind Parkinson disease?].Semantic proximity Read ↗

Histochemical features of stress-induced aggregates in alpha-synuclein overexpressing cells.Semantic proximity Read ↗

A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease.Semantic proximity Read ↗

Alpha-synuclein-induced oxidative stress correlates with altered superoxide dismutase and glutathione synthesis in human neuroblastoma SH-SY5Y cellsSemantic proximity Read ↗

6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation.Semantic proximity Read ↗

The reaction of alpha-synuclein with tyrosinase: possible implications for Parkinson disease.Semantic proximity Read ↗

Biomarkers of Cell Damage Induced by Oxidative Stress in Parkinsons Disease and Related ModelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.