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Article

Clinical implications of SOCS1 methylation in myelodysplastic syndrome.

British journal of haematology - 1 Nov 2006

Wu Shang-Ju, Yao Ming, Chou Wen-Chien, Tang Jih-Luh, Chen Chien-Yuan, Ko Bo-Sheng, Huang Shen-Yi, Tsay Woei, Chen Yao-Chang, Shen Ming-Ching, Wang Chiu-Hwa, Yeh Yo-Chia, Tien Hwei-Fang

Abstract excerpt

The suppressor of cytokine signalling-1 (SOCS1) protein is a tumour suppressor. Hypermethylation of SOCS1 gene, resulting in transcriptional silencing, is suggested to play an important role in cancer development. We sought to characterise SOCS1 methylation in primary myelodysplastic syndrome (MDS) and clarify its clinical implications. The methylation status of SOCS1 was analysed by methylation-specific...

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Source

Identifiers

PMID: 16978223
DOI: 10.1111/j.1365-2141.2006.06293.x

Genes

SOCS1
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Clinical implications of SOCS1 methylation in myelodysplastic syndrome.PMID 16978223Read ↗

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