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Article

SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma

17 Mar 2003

Abstract excerpt

The suppressor of cytokine signaling (SOCS) family of proteins has been implicated in the negative regulation of several cytokine pathways, particularly the receptor-associated tyrosine kinase/signal transducer and activator of transcription (Jak/STAT) pathways of transcriptional activation. SOCS-1 (also known as JAB and SSI-1) inhibits signaling by many cytokines. Because of the previously observed...

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PMID: 12456503
DOI: 10.1182/blood-2002-06-1735

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