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Article

Aberrant methylation of the negative regulators <i>RASSFIA</i>, <i>SHP‐1</i> and <i>SOCS‐1</i> in myelodysplastic syndromes and acute myeloid leukaemia

21 Mar 2005

Abstract excerpt

Mutations in the receptor tyrosine kinase (RTK/RAS) signalling pathway frequently provide a proliferative signal in myeloid malignancies. However, the role of RASSF1A, SHP-1 and SOCS-1, negative regulators of RTK/RAS signalling, has not been extensively investigated in the myelodysplastic syndromes (MDS) or acute myeloid leukaemia (AML). This study employed methylation-specific polymerase chain reaction (MS-PCR)...

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Identifiers

PMID: 15801956
DOI: 10.1111/j.1365-2141.2005.05412.x

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