Article
CpG island methylator phenotype of myelodysplastic syndrome identified through genome-wide profiling of DNA methylation and gene expression.
British journal of haematology - 1 Jun 2014
Zhao Xiaoli, Yang Feng, Li Shuang, Liu Meixia, Ying Shaoxu, Jia Xiaodong, Wang Xiaoqin
Abstract excerpt
The CpG island methylator phenotype (CIMP) is an epigenetic phenomenon and plays an important role in tumourigenesis in various cancers. The identification of aberrant DNA methylation can be exploited for early diagnosis and risk assessment of patients. We identified a CIMP in myelodysplastic syndrome (MDS). Genes were screened for hypermethylation and transcription downregulation through genome-wide DNA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.