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Article

Hypermethylation of the suppressor of cytokine signalling‐1 (<i>SOCS‐1</i>) in myelodysplastic syndrome

28 Jun 2005

Abstract excerpt

Transcriptional silencing because of hypermethylation is now recognised to be a hallmark of human tumours. In contrast to acute myeloid leukaemia (AML), comparably little is known about aberrant methylation in myelodysplastic syndrome (MDS), a heterogeneous clonal stem cell disorder with a risk of transformation into secondary AML of up to 30%. Recent evidence demonstrates that suppressor of cytokine signalling...

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PMID: 16029449
DOI: 10.1111/j.1365-2141.2005.05590.x

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Hypermethylation of the suppressor of cytokine signalling‐1 (<i>SOCS‐1</i>) in myelodysplastic syndromePMID 16029449Read ↗

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