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Article

Methylation of the suppressor of cytokine signaling 3 gene (SOCS3) in myeloproliferative disorders.

Haematologica - 1 Nov 2008

Fourouclas Nasios, Li Juan, Gilby Daniel C, Campbell Peter J, Beer Philip A, Boyd Elaine M, Goodeve Anne C, Bareford David, Harrison Claire N, Reilly John T, Green Anthony R, Bench Anthony J

Abstract excerpt

BACKGROUND: The JAK2 V617F mutation can be found in patients with polycythemia vera, essential thrombocythemia and idiopathic myelofibrosis. Mutation or methylation of other components of JAK/STAT signaling, such as the negative regulators suppressor of cytokine signaling 1 (SOCS1) and SOCS3, may contribute to the pathogenesis of both JAK2 V617F positive and negative myeloproliferative disorders. DESIGN AND...

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Source

Identifiers

PMID: 18815196
DOI: 10.3324/haematol.13043

Genes

SOCS3
JAK2
SOCS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Methylation of the suppressor of cytokine signaling 3 gene (SOCS3) in myeloproliferative disorders.PMID 18815196Read ↗

Epigenetic alteration of SOCS family members is a possible pathogenetic mechanism in JAK2 wild type myeloproliferative diseases.Semantic proximity Read ↗

Epigenetic inactivation of suppressors of cytokine signalling in Philadelphia-negative chronic myeloproliferative disorders.Semantic proximity Read ↗

[Study of hypermethylation of SOCS gene in typical myeloproliferative disease].Semantic proximity Read ↗

The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3.Semantic proximity Read ↗

Clinical implications of SOCS1 methylation in myelodysplastic syndrome.Semantic proximity Read ↗

Hypermethylation of the suppressor of cytokine signalling‐1 (<i>SOCS‐1</i>) in myelodysplastic syndromeSemantic proximity Read ↗

Suppressor of cytokine signalling‐1 gene silencing in acute myeloid leukaemia and human haematopoietic cell linesSemantic proximity Read ↗

Epigenomic profiling in polycythaemia vera and essential thrombocythaemia shows low levels of aberrant DNA methylationSemantic proximity Read ↗

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SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myelomaSemantic proximity Read ↗

One gene to rule them all – clinical perspectives of a potent suppressor of cytokine signaling – SOCS1Semantic proximity Read ↗

SOCS3 tyrosine phosphorylation as a potential bio-marker for myeloproliferative neoplasms associated with mutant JAK2 kinases.Semantic proximity Read ↗

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