Article
Tissue homeostasis and the control of the neoplastic phenotype in epithelial cancers.
Seminars in cancer biology - 1 Apr 2005
Glick Adam B, Yuspa Stuart H
Abstract excerpt
Neoplastic cells at various stages of tumor progression may remain dormant for many years. The suppression of the neoplastic phenotype and tumor outgrowth depends on close contact of neoplastic cells with surrounding normal cells. This review examines the nature of these contacts primarily in models for skin cancer induction. Junctional complexes, membrane associated growth factors and their receptors, and...
Topics
- Animals
- Carcinoma
- Cell Communication
- Gap Junctions
- Homeostasis
- Phenotype
- Skin Neoplasms
