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Article

Evaluation of the lytic origins of replication of Kaposi's sarcoma-associated virus/human herpesvirus 8 in the context of the viral genome.

Journal of virology - 1 Oct 2006

Xu Yiyang, Rodriguez-Huete Alicia, Pari Gregory S

Abstract excerpt

The lytic origins of DNA replication for human herpesvirus 8 (HHV8), oriLyt-L and oriLyt-R, are located between open reading frames K4.2 and K5 and ORF69 and vFLIP, respectively. These lytic origins were elucidated using a transient replication assay. Although this assay is a powerful tool for identifying many herpesvirus lytic origins, it is limited in its ability to evaluate the activity of replication origins...

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Identifiers

PMID: 16973596
DOI: 10.1128/JVI.01004-06
PMCID: PMC1617234

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