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Article

Construction of a Lytically Replicating Kaposi's Sarcoma-Associated Herpesvirus

28 Jul 2011

Abstract excerpt

Karposi's sarcoma-associated herpesvirus (KSHV) is found predominantly in a latent state in most cell types, impeding investigations of the lytic replication cycle. Here, we engineered the cloned KSHV genome, bacterial artificial chromosome 36 (BAC36), to enforce constitutive expression of the main lytic switch regulator, the replication and transcription activator (RTA) (open reading frame 50 [ORF50]). The...

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Identifiers

PMID: 21795351
DOI: 10.1128/jvi.05071-11

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