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Article

Overexpression of the kaposi's sarcoma-associated herpesvirus transactivator K-Rta can complement a K-bZIP deletion BACmid and yields an enhanced growth phenotype.

Journal of virology - 1 Dec 2007

Kato-Noah Taeko, Xu Yiyang, Rossetto Cyprian C, Colletti Kelly, Papousková Iva, Pari Gregory S

Abstract excerpt

Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (HHV8) ORF50 encodes a transactivator, K-Rta, which functions as the switch from latent to lytic virus replication. K-bZIP interacts with K-Rta and can repress its transactivation activity for some viral promoters. Both K-Rta and K-bZIP are required for origin-dependent DNA replication. To determine the role of K-bZIP in the context of the viral genome,...

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Share to Antigens, Viral
Share to Basic-Leucine Zipper Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Artificial, Bacterial

Share to Gene Expression Regulation, Viral

Share to Herpesvirus 8, Human

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Source

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Identifiers

PMID: 17913803
DOI: 10.1128/JVI.00832-07
PMCID: PMC2168825

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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