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Article

Human herpesvirus 6B origin: sequence diversity, requirement for two binding sites for origin-binding protein, and enhanced replication from origin multimers.

Journal of virology - 1 Oct 1994

Dewhurst S, Krenitsky D M, Dykes C

Abstract excerpt

A previously identified human herpesvirus 6B (HHV-6B) origin of DNA replication contains two binding sites for the origin-binding protein (OBPH6B). We have investigated the functional significance of these sites by determining the replication efficiencies of mutated origin sequences, using a transient replication assay. The results indicate that both sites are required for DNA replication. In addition, we have...

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Identifiers

PMID: 8084018
DOI: 10.1128/JVI.68.10.6799-6803.1994
PMCID: PMC237107

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