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Article

Characterisation of a human herpesvirus 6 variant A 'amplicon' and replication modulation by U94-Rep 'latency gene'.

Journal of virological methods - 1 Sept 2002

Turner Simon, DiLuca Dario, Gompels Ursula

Abstract excerpt

The human herpesvirus 6 (HHV-6) variant A genome has conserved sequences which are signals for initiating lytic replication (origin, 'ori-lyt') and DNA packaging into the virion (pac2/1). Here these are functionally characterised and used to construct a gene-expression amplifiable-vector, an 'amplicon', with applications for gene delivery to lymphoid-myeloid cells or their progenitor stem cells. A minimal...

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PMID: 12270665
DOI: 10.1016/s0166-0934(02)00130-1

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