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Analysis of Human Cytomegalovirus <i>ori</i> Lyt Sequence Requirements in the Context of the Viral Genome

24 Feb 2005

Abstract excerpt

During the lytic phase of infection, replication of herpesvirus genomes initiates at the lytic origin of replication, oriLyt. Many herpesviruses harbor more than one lytic origin, but so far, only one oriLyt has been identified for human cytomegalovirus (HCMV). Evidence for the existence of additional lytic origins of HCMV has remained elusive. On the basis of transient replication assays with cloned viral...

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Identifiers

PMID: 15731256
DOI: 10.1128/jvi.79.6.3615-3626.2005

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Analysis of Human Cytomegalovirus <i>ori</i> Lyt Sequence Requirements in the Context of the Viral GenomePMID 15731256Read ↗

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Open reading frames UL44, IRS1/TRS1, and UL36-38 are required for transient complementation of human cytomegalovirus oriLyt-dependent DNA synthesisSemantic proximity Read ↗

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