Article
Identification and functional characterization of the left origin of lytic replication of murine gammaherpesvirus 68.
Virology - 10 May 2009
Gong Danyang, Qi Jing, Arumugaswami Vaithilingaraja, Sun Ren, Deng Hongyu
Abstract excerpt
Murine gammaherpesvirus 68 (MHV-68) replicates robustly in cell culture, providing a model for studying viral genome replication during de novo infection of tumor-associated herpesviruses. We have previously identified a 1.25-kb origin of lytic replication (oriLyt) for MHV-68. To further investigate the molecular mechanism of viral genome replication, we first fine-mapped essential cis-elements from this oriLyt...
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