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Kaposi's Sarcoma-Associated Herpesvirus <i>ori-Lyt</i> -Dependent DNA Replication: DualRole of Replication and Transcription Activator

27 Nov 2006

Abstract excerpt

Lytic replication of Kaposi's sarcoma-associated herpesvirus (KSHV) is essential for viral propagation and pathogenicity. In Kaposi's sarcoma lesions, constant lytic replication plays a role in sustaining the population of latently infected cells that otherwise are quickly lost by segregation of latent viral episomes as spindle cells divide. Lytic DNA replication initiates from an origin (ori-Lyt) and requires...

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PMID: 17020951
DOI: 10.1128/jvi.00990-06

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