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Article

Aged mice exhibit distinct peripheral B-cell phenotypes differing in apoptotic susceptibility: an ex vivo analysis.

Cytometry. Part A : the journal of the International Society for Analytical Cytology - 1 Sept 2006

Verdier Mireille, Malissein Emilie, Munteanu Eliza, Jayat-Vignoles Chantal, Ratinaud Marie-Hélène, Troutaud Danielle

Abstract excerpt

BACKGROUND: Age-related changes in the antibody response have been classically associated with alterations in T-cell help, but increasing evidence shows that intrinsic B-cell defects exist. This article analyzes the apoptotic susceptibility of peripheral B-cells in aged and young control mice. MATERIALS AND METHODS: Freshly isolated lymphocytes from spleen and Peyer's patches (PPs) were labeled for B-cell lineage...

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PMID: 16969798
DOI: 10.1002/cyto.a.20310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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